Arkansas AD Long chosen selection committee chair

Arkansas athletic director Jeff Long will be the first chairman of the College Football Playoff selection committee, and the rest of the 13-member panel that will decide which teams play for the 2014 national championship will be officially revealed Wednesday.

The announcement of Long to lead the committee and act as a spokesman was made Monday.

A news conference will be held Wednesday at the College Football Playoff's new offices in Irving, Texas, with Long and executive director Bill Hancock unveiling the rest of the members.

The names of the other members expected to be on the committee, however, already have been reported by The Associated Press and other media outlets.

Long is among five current athletic directors, along with West Virginia's Oliver Luck, Wisconsin's Barry Alvarez, Clemson's Dan Radakovich and Southern California's Pat Haden.

Also expected on the committee are: Former Secretary of State Condoleezza Rice; retired Lt. Gen Michael Gould; former Big East Commissioner Mike Tranghese; former Nebraska coach Tom Osborne; former Notre Dame, Stanford and Washington coach Tyrone Willingham; former NFL and Mississippi quarterback Archie Manning; former NCAA vice president Tom Jernstedt; and former college sports writer Steve Wieberg.

The committee will pick the four teams to play in the national semifinals in the new postseason system that will replace the Bowl Championship Series after this season. The winners will play about a week later for the national championship.

Long has led the athletic department at Arkansas since 2008 after holding the same position at Pittsburgh. He played football and baseball at Ohio Wesleyan and worked on the football staffs at Rice, North Carolina State, Duke and Michigan.

"I'm very humbled and honored to serve as the first chairman of the College Football Playoff Selection Committee," Long said in a statement. "There is no doubt our task will be challenging. However, I am confident in the committee members' ability to determine the four best teams in college football. I look forward to getting to work."

Associated PressSource: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-10-14-Playoff%20Committee/id-65cbaf726b974854bbb7788de8acdf7d
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Cellular process critical to kidney health suppressed by obesity

Main Category: Urology / Nephrology

Also Included In: Obesity / Weight Loss / Fitness

Article Date: 08 Oct 2013 - 0:00 PDT

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Cellular process critical to kidney health suppressed by obesity

Obesity increases a chronic kidney disease patient's risk of developing kidney failure.

Obesity suppresses an important cellular process that prevents kidney cell damage, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that restoring the process could protect the kidney health of obese individuals.

Obesity increases a chronic kidney disease patient's risk of developing kidney failure, but the mechanism underlying this connection has remained unclear.

Kosuke Yamahara, Takashi Uzu, MD, PhD (Shiga University of Medical Science, in Japan), and their colleagues suspected that decreased functioning of a process called autophagy might play a role. Autophagy is a degradation system within cells that removes damaged proteins and other defective cellular components, and autophagy insufficiency is common in obese individuals.

The researchers found that in normal-weight mice with kidney disease, autophagy was active in kidney cells. However, in obese mice with kidney disease, autophagy was suppressed and kidney cells became damaged. Normal-weight mice with kidney disease and defective autophagy (due to a gene deletion) also experienced kidney cell damage.

The investigators also discovered that a potent suppressor of autophagy (called mTOR) was hyperactivated in the kidneys of obese mice, and treatment with an mTOR inhibitor ameliorated autophagy insufficiency. Furthermore, both mTOR hyperactivation and autophagy suppression were observed in kidney specimens from obese patients with kidney disease.

"Obesity suppresses autophagy via an abnormal activation of nutrition sensing signals in the kidney," said Yamahara. "Our results suggest that restoring the kidney-protective action of autophagy may improve the kidney health of obese patients."

In an accompanying editorial, Ken Inoki, PhD (University of Michigan) stated that "the results of this study provide an important pathomechanism underlying obesity-associated renal... cell damage."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.

Visit our urology / nephrology section for the latest news on this subject.

Study co-authors include Shinji Kume, Daisuke Koya, Yuki Tanaka, Yoshikata Morita, Masami Chin-Kanasaki, Hisazumi Araki, Keiji Isshiki, Shin-ichi Araki, Masakazu Haneda, Taiji Matsusaka, Atsunori Kashiwagi, and Hiroshi Maegawa.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions," online October 3, 2013, doi: 10.1681/ASN.2012111080.

The editorial, entitled "Proximal Tubules Forget “Self-Eating” When They Meet Western Meals ," online October 3, 2013, doi: 10.1681/ASN.2013070794.

American Society of Nephrology

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'Cellular process critical to kidney health suppressed by obesity'

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